Neu-REFIX is an allergen-free ß-glucan, unique for its source, as an exo-polysaccharide from Aureobasidium Pullulans, produced in GMP certified facility in Japan, possessing purity, functionality, water solubility and dosage standardization like a drug, preservable at room temperature, and orally consumable as such or with food. Immune modulatory effects in pre-clinical studies, in healthy Japanese volunteers and Covid-19 patients, showed its potentials as a disease modifying adjuvant, worth undertaking clinical trial in DMD, to yield beneficial effects by controlling inflammation and fibrosis.
Neu-REFIX reduced fibrosis, inflammation, enhanced muscle regeneration, in MDX mice and in a six-month-long clinical study in young boys, improved NSAA, 6MWT and MRC, and these disease modifying potentials were presented in MDA Conference 2023. Neu-REFIX, can be consumed at any stage of DMD, with standard of care medications. Therefore, it’s worth evaluating as a drug-adjuvant because, as reported, Neu-REFIX as a single agent, has helped accomplish, what the current disease modifying treatments, cell-based therapies, and angiogenesis approaches are together, trying to achieve, said Prof. Naoki Yamamoto, a co-researcher.
GNCorp, which spearheaded this accomplishment, has signed a MoU with MAP Healthcare, a subsidiary of SHBK International Holding Group, UAE and intends collaborating with like-minded organizations to validate Neu-REFIX in larger studies. Clinical research in Limb-Girdle Muscle Dystrophy (LGMD), multiple sclerosis and psoriasis are underway, to evaluate Neu-REFIX’s efficacy as a universal immune modulator.
*B-1,3-1,6 glucan is a listed food additive in MHLW, Japan; Not a drug or remedy to any illness. Research findings should not be construed as medical advice. Not GRAS, EFSA certified.
